Exploring Anti-Inflammatory Mechanisms of Onion Bioactive Compounds    with Module-Based Protein Interaction Network Analysis

Jidapa Sornsiri; Pitak Sootanan

Exploring Anti-Inflammatory Mechanisms of Onion Bioactive Compounds with Module-Based Protein Interaction Network Analysis

Jidapa Sornsiri, Pitak Sootanan

Abstract

Onion (Allium cepa L.) is a popular plant used as an ingredient in many dishes. This plant is a rich source of several natural active compounds, especially, flavonoids are enriched in onion and has pharmacological effects on the anti-inflammation. Biological network and module-base analysis can be employed to find a role and molecular mechanisms involving the anti-inflammation of flavonoid in onion. In this study, we aimed to use bioinformatic tools to search for potential target proteins, protein-protein interactions, and the proteins involving anti-inflammatory pathways. The module-based network analysis and biological interpretation were performed. From the analyses, we have found five active compounds in onions, relating to the MAPK and NF-

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